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The mitochondrial transporter family (SLC25): physiological and pathological implications

Interestingly, unlike mitochondrial ALDH2, the expression of two cytoplasmic ALDH1 isoforms (ALDH1A1 and ALDH1A3) is increased in -cells in T2D and this upregulation is associated with -cell de-differentiation (105108), suggesting they have additional roles beyond detoxifying RLAs